Authors: Ana Paula Mendes-Silva, Yuliya S Nikolova, Tarek K Rajji, James L Kennedy, Breno S Diniz, Vanessa F Gonçalves, Erica L Vieira

Publication date 2024/10/01 | Journal Journal of Affective Disorders

Background: Disrupted cellular communication, inflammatory responses and mitochondrial dysfunction are consistently observed in late-life depression (LLD). Exosomes (EXs) mediate cellular communication by transporting molecules, including mitochondrial DNA (EX-mtDNA), playing critical role in immunoregulation alongside tumor necrosis factor (TNF). Changes in EX-mtDNA are indicators of impaired mitochondrial function and might increase vulnerability to adverse health outcomes. Our study examined EX-mtDNA levels and integrity, exploring their associations with levels of TNF receptors I and II (TNFRI and TNFRII), and clinical outcomes in LLD.

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